Acuigen, genetics for aquaculture and conservation biological resources

Interests

I joined ACUIGEN en 2014 and I'm actually involved in a variety of research lines related to comparative genomics, genetic evolution, as well as the zebrafish xenograft model implementation for the evaluation and development of therapeutic lead molecules.

Selected publications

Figueras, A., Robledo, D.,  Corvelo, A., Hermida, M., Pereiro, P., Rubiolo, J.A., Gómez-Garrido, J., Carreté, L., Bello, X., Gut, M., Gut, I.G., Marcet-Houben, M., Forn-Cuní1, G., Galán, B., García, J.L., Abal-Fabeiro, J.L., Pardo, B.G., Taboada, X., Fernández, C., Vlasova, A., Hermoso-Pulido, A., Guigó, R., Álvarez-Dios, J.A., Gómez-Tato, A., Viñas, A., Maside, X., Gabaldón, T., Novoa, B., Bouza, C., Alioto, T. and Martínez, P. 2016. Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): A fish adapted to demersal life. DNA Res doi: 10.1093/dnares/dsw007.

Rubiolo J.A., Vale C., Martín V., Fuwa H., Sasaki M., Botana L.M  2015. Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation. Arch Toxicol. 89(7): 1119-34.

Rubiolo J.A., López-Alonso H., Martínez P., Millán A., Cagide E., Vieytes M.R., Vega F.V., Botana L.M. 2014. Yessotoxin Induces Er-Stress Followed By Autophagic Cell Death In Glioma Cells Mediated By mTOR and BNIP3. Cell Signal. 26(2): 419-32.

Rubiolo J.A., López-Alonso H., Roel M., Vieytes M.R., Thomas O., Ternon E., Vega F.V., Botana L.M.  2014. Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells. Br. J. Pharmacol. 171(7): 1655-67.

Rubiolo J.A., López-Alonso H., Alfonso A., Vega F.V., Vieytes M.R., Botana L.M.  2012. Characterization and activity determination of the human protein phosphatase 2A catalytic subunit α expressed in insect larvae. Appl. Biochem. Biotechnol. 167(4): 918-28.